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Looking at the IIS logs this specifically is a 503 0 0 on the get verb on Exchange virtual directory
This KB helps here https://support.microsoft.com/kb/823159
Found a couple of instances of needing HKCRScan and this finding a key that is problematic (contact MS support for this tool)
They typically start Nxxxxxxxxx
Perhaps put in by NetApp? At least ive seen them put in by NetApp