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If you haven't done so already I recommend you take a look at our latest Biztalk Services CTP from the Connected Systems Division (https://connectedsystems.spaces.live.com/).
Quite a few people has already commented on this and I will just forward you to some of the links I have found interesting:
https://blogs.msdn.com/stevemar/
https://blogs.msdn.com/clemensv/archive/2007/04/25/internet-service-bus.aspx
Have Fun!