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If you have a __clrcall virtual function, the vtable will be per application ___domain (appdomain). If you create an object in one appdomain, you can only call the virtual function from within that appdomain. All functions defined in /clr:pure compilands use the __clrcall calling convention. Therefore, all vtables defined in /clr:pure compilands are per appdomain. In mixed mode (/clr) you will have per process vtables if your type has no __clrcall virtual functions.
For more information, see